UniProt
MCP server by smaniches
Look up UniProt proteins, diseases and variants, with release and SHA-256 provenance on every response.
Install UniProt
Runs on your machine. Your client starts it with this command:
Needs uv (Python) on your computer. The setup steps below show where the command goes in each client.
Share this server
Opens this page, with the install command and setup steps.
mcp.tc/i/uniprotAbout
Connects to the UniProt REST API and linked scientific sources to find proteins and assemble protein, target and variant evidence. Each successful response records the UniProt release, retrieval time, resolved source URL and a SHA-256 digest, so results can be checked later.
Runs locally over stdio from the PyPI package uniprot-mcp-server, started with uvx. The documentation lists no API key or sign-in requirement. Network access to UniProt is needed.
What you can do
- Fetch UniProt entries by accession with function and gene data
- Get disease associations for a protein
- Look up a specific variant such as R175H
- Record UniProt release, source URL and SHA-256 per response
- Verify later whether an upstream record is unchanged or has drifted
Tools
Local servers list their tools once they’re running, so we can’t show them here. Look for the list in its documentation; your client shows them after you add it.
Example prompts
What is the function of human p53 (P04637) and which diseases is it linked to?
Is R175H a documented disease variant in TP53?
Verify that the UniProt record for P04637 is unchanged since release 2026_01.
Build a protein evidence summary for BRCA1 with source provenance.
Set up
Every client starts UniProt on your machine with the same command. Pick yours; the page remembers your choice.
Claude Code
- Run this in a terminal, in your project folder:
claude mcp add --transport stdio uniprot -- uvx uniprot-mcp-server- Start Claude Code and type
/mcp. uniprot should show as connected.
Add --scope user to make it available in every project.
Claude Desktop
- Open Settings → Developer → Edit Config. It opens
claude_desktop_config.json. Add:
{
"mcpServers": {
"uniprot": {
"command": "uvx",
"args": [
"uniprot-mcp-server"
]
}
}
}- Save the file and restart Claude Desktop.
Needs uv (Python) on your computer. The file lives in ~/Library/Application Support/Claude/ on macOS and %APPDATA%\Claude\ on Windows.
Cursor
Add to Cursor (opens in a new tab)
Or add it by hand to ~/.cursor/mcp.json (all projects) or .cursor/mcp.json (this project):
{
"mcpServers": {
"uniprot": {
"command": "uvx",
"args": [
"uniprot-mcp-server"
]
}
}
}Needs uv (Python) on your computer.
VS Code
Install in VS Code (opens in a new tab)
Or from a terminal:
code --add-mcp '{"name":"uniprot","type":"stdio","command":"uvx","args":["uniprot-mcp-server"]}'Or commit it to the repo in .vscode/mcp.json:
{
"servers": {
"uniprot": {
"type": "stdio",
"command": "uvx",
"args": [
"uniprot-mcp-server"
]
}
}
}Needs uv (Python) on your computer.
Devin Desktop
- Add it to
~/.config/devin/mcp_config.json(macOS and Linux) or%APPDATA%\devin\mcp_config.json(Windows):
{
"mcpServers": {
"uniprot": {
"command": "uvx",
"args": [
"uniprot-mcp-server"
]
}
}
}- Refresh the MCP server list in Cascade.
Devin Desktop is the new name for Windsurf.
Codex
codex mcp add uniprot -- uvx uniprot-mcp-serverOr edit ~/.codex/config.toml directly:
[mcp_servers.uniprot]
command = "uvx"
args = ["uniprot-mcp-server"]Needs uv (Python) on your computer.
Gemini CLI
gemini mcp add uniprot uvx uniprot-mcp-serverThis adds it to the current project. Add -s user to use it everywhere.
Any client
Most clients that start local servers accept this shape:
{
"mcpServers": {
"uniprot": {
"command": "uvx",
"args": [
"uniprot-mcp-server"
]
}
}
}Zed puts servers under context_servers in its settings, with the same command, args and env fields.
Needs uv (Python) on your computer.
Embed
Show UniProt in a README or on your site. Each embed links to this page, uses the server’s own install command, and sets no cookies. How embeds work
The card, the iframe and the JSON are in English. Add ?lang=it, fr, de or es to their address for another language.
README badge
[](https://mcp.tc/i/uniprot)<a href="https://mcp.tc/i/uniprot"><img src="https://mcp.tc/i/uniprot/badge.svg" alt="UniProt on mcp.tc" height="20"></a>It follows the reader’s light or dark mode. Add ?theme=light or ?theme=dark to fix it, or ?style=compact to show the mark without the word.
Website card
<script src="https://mcp.tc/w/uniprot.js" async></script>The card appears where the tag is. Add data-theme="dark" or data-size="compact" to the tag to change it. The file holds everything it needs, so it makes no other requests and sets no cookies.
iframe
<iframe src="https://mcp.tc/embed/uniprot" title="UniProt on mcp.tc" width="420" height="200" loading="lazy" allow="clipboard-write" style="border:0;border-radius:8px;max-width:100%"></iframe>Use it on pages that don’t allow scripts. Add ?theme=light or ?theme=dark to the address to fix the colors.
JSON
The listing as data for your own pages and tools: name, tagline, install command, tools and the “Add to” links. Any site can read it (CORS is open).
https://mcp.tc/i/uniprot.jsonAI prompt
Paste this into an AI coding assistant, such as Claude Code or Cursor, and it adds the UniProt card to your site.
Add the mcp.tc card for UniProt, an MCP server, to my website. It is one static script: no build step, no package to install, no cookies.
Put this tag where the card should appear. The card renders right before it:
```html
<script src="https://mcp.tc/w/uniprot.js" async></script>
```
To show the card somewhere else, put this placeholder there and load the same script once, for example before `</body>`. Keep the link inside: visitors without JavaScript see it.
```html
<div data-mcptc="uniprot"><a href="https://mcp.tc/i/uniprot">UniProt on mcp.tc</a></div>
```
Options:
- `data-theme="light"` or `"dark"` on the tag or the placeholder fixes the colors. Without it, the card follows the visitor’s light or dark mode.
- `data-size="compact"` gives a smaller card without the tagline.
- The CSS variable `--mcptc-max-width` on the placeholder or a parent sets the width (default `520px`).
- `?lang=` on the script URL sets the card’s language: `en`, `it`, `fr`, `de` or `es`.
If the site has a Content Security Policy, allow `script-src https://mcp.tc` and `img-src data:` (the icon is inline).
For a README or other Markdown docs, use the badge instead:
```markdown
[](https://mcp.tc/i/uniprot)
```
Reference: https://mcp.tc/embedChange history
This server runs on your computer, so we follow its PyPI package: each new version shows up here, with edits by its owner.
FAQ
Can I paste mcp.tc/i/uniprot into my MCP client?
No. UniProt runs on your own computer, started by your client, so it has no web address to connect to. The quick link is the page to share; the install command is uvx uniprot-mcp-server.
Does UniProt need an API key?
No. It doesn’t declare any keys or environment variables. It runs with your user account’s permissions, so check what its tools can reach.
Is UniProt a remote or a local server?
Local. Your client starts it as a process on your computer with uvx uniprot-mcp-server, which needs uv (Python).
What can UniProt do?
You can fetch UniProt entries by accession with function and gene data, get disease associations for a protein and look up a specific variant such as R175H.
Which clients can use it?
Any client that starts local servers: Claude Code, Claude Desktop, Cursor, VS Code, Devin Desktop, Codex, Gemini CLI, Zed and others. claude.ai and ChatGPT only connect to remote servers.
Does mcp.tc track changes to UniProt?
Partly. It runs on your computer, so we follow its PyPI package: its History tab shows each new version and edits by its owner. Follow the listing to get an email when it changes.
Who wrote this page?
mcp.tc’s robot read UniProt’s public metadata (its package and repository pages), and an AI model drafted the text from it. A person reviews anything the checks can’t confirm. The text can still be wrong, so if you spot a mistake, use Report this listing on this page.
mcp.tc isn’t affiliated with smaniches. This page was built from UniProt’s public metadata, last checked on 5 Oct 2026, and an AI model wrote the description, so it can be wrong. Names and marks belong to their owners. Something off? Report this listing.